The Office of Defects Investigations (ODI) is an office within the NHTSA which investigates serious safety problems in the design, construction or performance of vehicles. The NHTSA is authorized to order manufacturers to recall and repair vehicles, if the ODI finds a safety issue. NHTSA investigations for the 2016 Ford F-250, both ongoing and closed, are listed below:

1. Currently there are no NHTSA investigations for the 2016 Ford F-250.