Some 2018-2021 Expedition/Navigator, 2018-2020 F-150/Mustang and 2019-2021 Ranger vehicles equipped with a 10R80 automatic transmission may exhibit an illuminated malfunction indicator lamp (MIL) with diagnostic trouble code (DTC) P163E stored in the powertrain control module (PCM) or transmission control module (TCM) after replacing the main control valve body. This may be due to software incompatibility between the replacement main control valve body solenoid strategy file and the PCM/TCM software. To correct this condition, follow the Service Procedure to obtain a new main control valve body with a new strategy number.