I started hearing a noise under the vehicle when I was between 35-40 mph. It would happen about once every 30 minutes. I thought it sounded like it was coming from the right, front tire.

I had my mechanic check it out when I had the vehicle in for state inspection. He drove the car and said he heard the same problem. After investigating he reported that the transmission was starting to fail, and it would be 4500-5000 dollars to find a rebuilt transmission. He said there is no guaranteed that a rebuilt one will last any longer and I am likely throwing my money away and I should consider getting a new vehicle. He also said this is a known problem with Honda Accord, Odyssey, and Pilot, and it usually happens around 100K miles.